Perennially stoned Cheech and Chong tear through the city of Los Angeles, causing trouble wherever they go. After Cheech loses his job, the two pot enthusiasts head to the welfare offices where Cheech's girlfriend, Donna, works. Instead of collecting unemployment, they find themselves thrown back on the streets, searching for a way to earn new income. But when Cheech's cousin, "Red" Mendoza, arrives, things get even crazier.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

After their mother suffers a fatal overdose, two sisters fear being separated by the foster system and decide to hide her body. But when their lie risks being exposed, they must decide how far they’re willing to go to keep their secret.

A mother helps her daughter work through four crucial days of recovery from substance abuse.

Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

Nina Geld's passion and talent have made her a rising star in the comedy scene, but she's an emotional mess offstage. When a new professional opportunity coincides with a romantic one, she is forced to confront her own deeply troubled past.

A manic-depressive mess of a father tries to win back his wife by attempting to take full responsibility of their two young, spirited daughters, who don't make the overwhelming task any easier.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

After getting into a car accident while drunk on the day of her sister's wedding, Gwen Cummings is given a choice between prison or a rehab center. She chooses rehab, but is extremely resistant to taking part in any of the treatment programs they have to offer, refusing to admit that she has an alcohol addiction.

Angela and Jessie are best friends intent on taking a wild beach trip, but when their roommate loses all of their money in a drug scam, the girls -- blissfully stoned -- go to increasingly daring and absurd lengths to get it back.

Agnes and her two sisters struggle through a day in a home overrun by gamblers, thieves, and johns.

A chaotic intervention. An action-packed stay in rehab. After a weird couple of years, John Mulaney comes out swinging in his return to the stage.

In East Los Angeles, an 18-year-old struggles between her ambitions of going to college and the desires of her domineering mother for her to get married, have children, and oversee the small, rundown family-owned textile factory.

When a self-destructive teenager is suspended from school and asked to look after his feisty alcoholic grandmother as a punishment, the crazy time they spend together turns his life around.

A college freshman returns to Los Angeles for Christmas at his ex-girlfriend's request, but discovers that his former best friend has an out-of-control drug habit.

In 1977, an idealistic porn producer and his promising protege try to catch up with the end of an era before their never-ending party collides with cold, hard reality.

In 1976, four working-class friends come of age in The Hamptons, on the South Shore of Long Island, New York, as clam diggers, as were their fathers and their grandfathers before them. They must cope with and learn to face the changing times in both their personal lives and their neighborhood.

In the late 1990s, up-and-coming mixed martial artist Mark Kerr aspires to become the greatest fighter in the world. However, he must also battle his opioid dependence and a volatile relationship with his girlfriend Dawn.