Claire Gregory, an upper class New York personality, witnesses a murder in a luxurious nightclub. Detective Mike Keegan, recently promoted, is assigned to protect her.

Private investigator Matthew Scudder is hired by a drug kingpin to find out who kidnapped and murdered his wife.

Two veteran New York City detectives work to identify the possible connection between a recent murder and a case they believe they solved years ago; is there a serial killer on the loose, and did they perhaps put the wrong person behind bars?

A serial killer is stalking New York City. Inspector Edward Delaney is an NYPD detective, nearing retirement, who is trying to put together the pieces of the case. Are the victims somehow linked? What does the brutal method of death signify?

An embattled NYPD detective, is thrust into a citywide manhunt for a pair of cop killers after uncovering a massive and unexpected conspiracy. As the night unfolds, lines become blurred on who he is pursuing, and who is in pursuit of him.

Lincoln Rhyme was the department's top homicide detective and leading expert in criminal forensics until an injury left him paralyzed, depressed, and incapable of working. But when a gruesome murder in Manhattan leaves detectives baffled, they call on Rhyme to help solve the mystery. Amelia Donaghy, a rookie cop whose quick thinking preserved a gruesome murder scene, is enlisted by Rhyme to be his on-the-scene forensics expert. With Amelia reluctantly acting as Rhyme's able-bodied go-between, the pair piece together cryptic clues the killer leaves behind at the scene of the crime, hoping to catch the grisly serial killer.

An unconventional undercover Chicago cop and his partner are recruited to commit the murder of a New Orleans criminal kingpin.

When his young son vanishes, a widower enlists help from his estranged father, a retired detective who put away the serial killer now linked to the case.

When 4 year old Amanda McCready disappears from her home and the police make little headway in solving the case, the girl's aunt, Beatrice McCready hires two private detectives, Patrick Kenzie and Angie Gennaro. The detectives freely admit that they have little experience with this type of case, but the family wants them for two reasons—they're not cops and they know the tough neighborhood in which they all live.

Mysterious Orfamay Quest hires Los Angeles private investigator Philip Marlowe to find her missing brother. Though the job seems simple enough, it leads Marlowe into the underbelly of the city, turning up leads who are murdered with ice picks, exotic dancers, blackmailed television stars, and self-preserving gangsters. Soon, Marlowe's life is on the line right along with his case.

Homicide detective John Hobbes witnesses the execution of serial killer Edgar Reese. Soon after the execution the killings start again, and they are very similar to Reese's style.

Failed actress Alex Sternbergen wakes up hungover one morning in an apartment she does not recognize, unable to remember the previous evening -- and with a dead body in bed next to her. As she tries to piece together the events of the night, Alex cannot totally rely on friends or her estranged husband, Joaquin, for assistance. Only a single ally, loner ex-policeman Turner Kendall, can help her escape her predicament and find the true killer.

Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.

Nick Hume is a mild-mannered executive with a perfect life, until one gruesome night he witnesses something that changes him forever. Transformed by grief, Hume eventually comes to the disturbing conclusion that no length is too great when protecting his family.

Alex is going through a midlife crisis and it has become a very difficult time for him. His marriage is struggling, he's worried about his son, and his job of killing people for his family has become the most stressful part of his life. He seeks the help of a therapist and meets a woman in the waiting room that he connects with.

Wealthy writer Stephen Byrne tries to seduce the family maid, but when she resists, he kills her. Long jealous of his brother John, Stephen does his best to pin the blame for the murder on his sibling. Also affected by Stephen's arrogant dementia is his long-suffering wife Marjorie.

Julian makes a lucrative living as an escort to older women in the Los Angeles area. He begins a relationship with Michelle, a local politician's wife, without expecting any pay. One of his clients is murdered and Detective Sunday begins pumping him for details on his different clients, something he is reluctant to do considering the nature of his work. Julian begins to suspect he's being framed. Meanwhile Michelle begins to fall in love with him.

A violent screenwriter and a female neighbor fall in love after she clears him of murder, but she begins to have second thoughts.

Freddy Heflin is the sheriff of a place everyone calls “Cop Land” — a small and seemingly peaceful town populated by the big city police officers he’s long admired. Yet something ugly is taking place behind the town’s peaceful facade. And when Freddy uncovers a massive, deadly conspiracy among these local residents, he is forced to take action and make a dangerous choice between protecting his idols and upholding the law.

When Lou Bloom, desperate for work, muscles into the world of L.A. crime journalism, he blurs the line between observer and participant to become the star of his own story. Aiding him in his effort is Nina, a TV-news veteran.